OrangerV1, Main, Exploration, bibRecord, 002888

Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

Identifieur interne : 002888 ( Main/Exploration ); précédent : 002887; suivant : 002889

Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

Auteurs : Jari J. Lilja [Finlande] ; Laura Juntti-Patinen ; Pertti J. Neuvonen

Source :

Clinical pharmacology and therapeutics [ 0009-9236 ] ; 2004.

RBID : pubmed:15001969

English descriptors

KwdEn :
- Adrenergic beta-Antagonists (blood), Adrenergic beta-Antagonists (pharmacokinetics), Adrenergic beta-Antagonists (urine), Adult, Area Under Curve, Beverages, Biological Availability, Celiprolol (antagonists & inhibitors), Celiprolol (blood), Celiprolol (pharmacokinetics), Celiprolol (urine), Citrus sinensis, Cross-Over Studies, Female, Food-Drug Interactions, Humans, Male, Receptors, Adrenergic, beta (metabolism), Statistics, Nonparametric.
MESH :
- chemical , antagonists & inhibitors : Celiprolol.
- chemical , blood : Adrenergic beta-Antagonists, Celiprolol.
- chemical , metabolism : Receptors, Adrenergic, beta.
- chemical , pharmacokinetics : Adrenergic beta-Antagonists, Celiprolol.
- chemical , urine : Adrenergic beta-Antagonists, Celiprolol.
- Adult, Area Under Curve, Beverages, Biological Availability, Citrus sinensis, Cross-Over Studies, Female, Food-Drug Interactions, Humans, Male, Statistics, Nonparametric.

Abstract

Grapefruit juice was recently found to decrease plasma concentrations of the beta-adrenergic receptor-blocking agent celiprolol. Our objective was to investigate the effect of orange juice on the pharmacokinetics of celiprolol in healthy subjects.

DOI: 10.1016/j.clpt.2003.11.002
PubMed: 15001969

Affiliations:

Finlande

Le document en format XML

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<author><name sortKey="Lilja, Jari J" sort="Lilja, Jari J" uniqKey="Lilja J" first="Jari J" last="Lilja">Jari J. Lilja</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290, Finland. jari.lilja@hus.fi</nlm:affiliation>
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<wicri:regionArea>Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290</wicri:regionArea>
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<author><name sortKey="Juntti Patinen, Laura" sort="Juntti Patinen, Laura" uniqKey="Juntti Patinen L" first="Laura" last="Juntti-Patinen">Laura Juntti-Patinen</name>
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<author><name sortKey="Neuvonen, Pertti J" sort="Neuvonen, Pertti J" uniqKey="Neuvonen P" first="Pertti J" last="Neuvonen">Pertti J. Neuvonen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.</title>
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<author><name sortKey="Juntti Patinen, Laura" sort="Juntti Patinen, Laura" uniqKey="Juntti Patinen L" first="Laura" last="Juntti-Patinen">Laura Juntti-Patinen</name>
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<series><title level="j">Clinical pharmacology and therapeutics</title>
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<term>Adrenergic beta-Antagonists (pharmacokinetics)</term>
<term>Adrenergic beta-Antagonists (urine)</term>
<term>Adult</term>
<term>Area Under Curve</term>
<term>Beverages</term>
<term>Biological Availability</term>
<term>Celiprolol (antagonists & inhibitors)</term>
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<term>Food-Drug Interactions</term>
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<term>Male</term>
<term>Receptors, Adrenergic, beta (metabolism)</term>
<term>Statistics, Nonparametric</term>
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<term>Celiprolol</term>
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<term>Cross-Over Studies</term>
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<front><div type="abstract" xml:lang="en">Grapefruit juice was recently found to decrease plasma concentrations of the beta-adrenergic receptor-blocking agent celiprolol. Our objective was to investigate the effect of orange juice on the pharmacokinetics of celiprolol in healthy subjects.</div>
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<country name="Finlande"><noRegion><name sortKey="Lilja, Jari J" sort="Lilja, Jari J" uniqKey="Lilja J" first="Jari J" last="Lilja">Jari J. Lilja</name>
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</record>

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Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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